What is the exposome?
The term exposome was first introduced in 2005 by the cancer epidemiologist Dr. Christopher Wild (Wild et al., 2005). It refers to a non-genetic complex interaction between external & internal exposures to the human body or a specific organ throughout its lifespan (environmental factors, diet, lifestyle and social influences). The exposome complements genetic stimuli that the human body is subjected to.
For the past decade, advances have been made to further elaborate this concept. Understanding the relationship between the human body and the totality of factors to which it is exposed would complement genetic information and aid in explaining the development of some chronic diseases and could provide a basis for new strategies of prevention and /or protection.
Why is the study of exposome important in dermatology and skin care?
The skin is the largest organ in the human body. It is a protective, highly interactive barrier with its surrounding environment. As a barrier organ, the skin is most affected by its surrounding environment. Like any other organ in the body, its health is a combination of genetics and environment. Therefore, understanding the totality of exposome factors it is subjected to and consequent results is of utmost importance.
Previous work had established the significant impact of the exposome on aging skin (Krutman et al., 2017), as well as acne (Dremo et al., 2018). In concordance with these findings, a recent ongoing study is revealing that exposome factors have an impact on the skin’s immune system.
Vichy at the heart of scientific advancement
Even though work around the exposome has existed for the past decade, findings remain limited and exposing the exposome’s impact and underlying pathophysiological mechanisms affecting the skin’s health remain to be uncovered. A better understanding of this area is in concordance with Vichy Laboratoires’ commitment to achieving excellence in understanding human skin health (Salsberg et al., 2019). Throughout the Vichy exposome grant initiated in 2016, Vichy Laboratoires continue to endorse this under-explored but highly important area of research.
The main objective of the grant is to boost a scientific interest in skin exposome by bringing together high calibre health and skin health researchers.
Previous winners of the Vichy exposome grant:
The winner of the 2016 Vichy Exposome Grant, Dr Tamara Schikowski based at IUF Leibniz Research Institute for Environmental Medicine, Germany, worked on analysing the synergies between air pollutants and UV exposure that may result in accelerated skin ageing.
The winner of the 2017 Vichy Exposome Grant, Dr Agatha Schwarz based at UKSH, Kiel, Schleswig-Holstein, Germany, is currently working on skin microbiome-derived short chain fatty acids as modulators of the skin immune system.
The winner of the 2018 Vichy Exposome Grant, Pr Christine Moissl-Eichinger based at the Department of Internal Medicine, Joint Facilities, Graz Medical University, Austria is currently working on understanding the composition and functional stability of microorganisms on human skin in the presence of typical exposures like desiccation, UV-radiation, temperature, moisture, pH and cosmetic products. Her findings will help retrieve critical information on the impact of the exposome on the archaeal and bacterial skin microbiome and to evaluate a potential use of skin probiotics.
About Vichy Laboratoires
Created in 1931 by Dr. Haller, Vichy Laboratoires was born in the region of Auvergne, near the French Volcanoes. Vichy skincare products are created with water charged with 15 essential minerals, proven to strengthen skin to help fight against aggressions and are coupled with powerful active ingredients. Assessed under strict quality conditions just four kilometers from the source of Vichy mineralizing water, Vichy products are formulated to ensure safety, and efficacy for sensitive skin.
Complementing the genome with an exposome: the outstanding challenge of environmental exposure measurement in molecular epidemiology
Cancer Epidemiol. Biomarkers Prev., 14 (8)(2005), pp. 1847-1850
The skin aging exposome.
Krutmann J1, Bouloc A2, Sore G3, Bernard BA4, Passeron T5.
J Dermatol Sci. 2017 Mar;85(3):152-161. doi: 10.1016/j.jdermsci.2016.09.015. Epub 2016 Sep 28.
The influence of exposome on acne.
Dréno B1, Bettoli V2, Araviiskaia E3, Sanchez Viera M4, Bouloc A5.
J Eur Acad Dermatol Venereol. 2018 May;32(5):812-819. doi: 10.1111/jdv.14820. Epub 2018 Feb 15.
A review of protection against exposome factors impacting facial skin barrier function with 89% mineralizing thermal water.
Salsberg J1, Andriessen A2, Abdulla S3, Ahluwalia R4, Beecker J5, Sander M6, Schachter J7.
J Cosmet Dermatol. 2019 Jun;18(3):815-820. doi: 10.1111/jocd.12927. Epub 2019 Apr 9.
An absolute priority: product safety
In 1909 when Eugene Schueller created the « Société des teintures inoffensives » that was to become L'Oréal, he was a pioneer. Since then, the group has continuously invested in the evaluation of the safety of its products and the ingredients from which they are made. Thanks to its constant scientific commitment, L'Oréal has contributed to progress in knowledge about toxicology*. Today,thanks especially to predictive evaluation to which the group has dedicated an ultramodern global center in 2011, the teams know how to make very early and reliable predictions on the undesirable and beneficial effects of ingredients and products.
* the study of harmful effects of substances on an organism
To be in the service of beauty is also to preserve the beauty of our planet. L'Oréal has always been one step ahead of the regulatory provisions regarding the environment. As early as 1995, the Group acquired an eco-toxicology laboratory to measure and model the potential impact of products on the ecosystems (water, soil, air) and on biodiversity. In 1999, it adopted the principles of green chemistry for the synthesis of ingredients. Since 2006, its portfolio of raw materials has been under constant monitoring for environmental indicators. Innovation processes are in compliance with the guidelines for ecodesign that reduce the impact of products on the environment throughout their whole life cycle. These guidelines are shared with the suppliers and partners.